Role of irisin in improving glucose levels,lipid metabolism,and obesity

VernacularTitle:鸢尾素在糖脂代谢及肥胖中的作用
Author: Yiping ZHANG ¹ ; Jing DING ; Yi ZHANG ; Yutong JIANG ; Jiwei QIU ; Yingliang WEI
Author Information

1. 中国医科大学第二临床学院,沈阳 110122
Keywords: exercise; irisin; glucose and lipid metabolism; browning of white fat; insulin resistance
From: Journal of China Medical University 2024;53(7):646-650
CountryChina
Language:Chinese
Abstract: As a metabolic disease,obesity increases the risk of many chronic metabolic diseases;in fact,it is an epidemic in the 21st cen-tury.Exercise is an important means of controlling and treating obesity.Irisin,a myocyte cytokine,was discovered and reported in 2012;it is regulated by exercise and involved in the browning of adipose tissue.A recent discovery is irisin's ability to improve obesity,which is embodied in its effect on glucose and lipid metabolism.Irisin can induce the browning of white fat;promote glucose homeostasis;resist the damage of fat cells caused by inflammation,oxidative stress,and other factors;inhibit insulin resistance;and improve glucose,lipid metabolism,and obesity.This review addresses the role of irisin in improving glucose levels,lipid metabolism,and obesity,as well its role in regulating exercise.Further,the prospect of future research is discussed.