Research progress on transmembrane protein 16A and its inhibitors
10.12007/j.issn.0258-4646.2024.05.014
- VernacularTitle:跨膜蛋白16A及其抑制剂的研究进展
- Author:
Pengfei DI
1
;
Siyu CHEN
;
Hongming YANG
;
Qinghuan XIAO
;
Shuya LUO
Author Information
1. 中国医科大学第一临床学院
- Keywords:
transmembrane protein 16A;
calcium-activated chloride channel;
inhibitor;
cancer;
research progress
- From:
Journal of China Medical University
2024;53(5):468-472
- CountryChina
- Language:Chinese
-
Abstract:
Transmembrane protein 16A(TMEM16A)is a voltage-dependent calcium-activated chloride channel that is widely expressed in cancer cells.In a variety of cancer types,TMEM16A regulates the proliferation,invasion,and metastasis of cancer cells and is corre-lated with the prognosis of cancer under treatment.In recent years,TMEM16A and its inhibitors have been intensively studied in cancer treatment.This review summarizes relevant studies conducted over the past 10 years,aiming to provide a novel therapeutic strategy for the clinical application of TMEM16A inhibitors in future cancer therapy.
