Role of macrophages and their exosomes in orthopedic diseases
10.12007/j.issn.0258-4646.2024.05.013
- VernacularTitle:巨噬细胞及其外泌体在骨科疾病中的作用
- Author:
Riming YUAN
1
;
Jianjun LI
Author Information
1. 中国医科大学附属盛京医院创伤骨科,沈阳 110004
- Keywords:
macrophage;
exosome;
fracture;
osteosarcoma;
rheumatoid arthritis
- From:
Journal of China Medical University
2024;53(5):464-467,472
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are vesicles with a lipid bilayer structure that carry various active substances,such as proteins,DNA,non-coding RNA,and nucleic acids.They participate in the immune response,tissue formation,and cell communication.Macrophages,as phagocytes in vivo,engulf various cellular and tissue fragments.Further,phagocytes exhibit different phenotypes(M1 and M2)according to in vivo changes in the microenvironment.M1 macrophages play an inflammatory role,whereas M2 macrophages play an anti-inflammatory role.In addition,macrophages and their exosomes are closely related to fracture healing and osteosarcoma,rheumatoid arthritis,and other orthopedic diseases.This review highlights the strong correlation between macrophages,their exosomes,and orthopedic diseases.
