Clinical and Histopathologic Findings on the Abnormal Liver Function Complicated with Kawasaki Disease.
- Author:
Sung Chul LEE
1
;
Hann TCHAH
;
Song Yi NA
;
Hee Sup KIM
;
Ho JIn PARK
;
Mi Kyeong SHIN
Author Information
1. Department of Pediatrics, Seoul Red Cross Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Kawasaki disease;
Alanine aminotransferase (ALT);
Histopathologic findings
- MeSH:
Alanine Transaminase;
Anemia;
Aneurysm;
Bile Ducts;
Biopsy;
Cholecystitis;
Dilatation;
Edema;
Electrocardiography;
Female;
Fever;
Hospitalization;
Humans;
Leukocytosis;
Liver Function Tests;
Liver*;
Lymphatic Diseases;
Lymphocytes;
Male;
Mucocutaneous Lymph Node Syndrome*;
Prognosis;
Sex Distribution;
Thrombocytosis
- From:Korean Journal of Pediatric Gastroenterology and Nutrition
2000;3(1):47-55
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this research is to examine the abnormal liver function complicated with Kawasaki disease (KD) and to analyze its clinical characteristics and complications. METHODS: Ninty eight cases were diagnosed as having KD, among which thirty four cases had abnormal alanine aminotransferase (ALT) (>30 IU/L). These abnormal ALT cases were evaluated in terms of age and sex distribution, major symptoms, complications, laboratory and histopathologic findings. RESULTS: Male to female ratio was 2.4 : 1 and most patients (91.2%) were under 5 years of age. Cervical lymphadenopathy was observed in 3 cases (8.8%); and recurred cases were two (5.8%). Average fever duration was 8 days: average length of hospitalization was 9 days; and average recovery period was 13 days. Immediately after admission, positive CRP was observed in 31 cases (91.2%), leukocytosis (>10,000/mm(3)) in 26 cases (76.0%), thrombocytosis (>450,000/mm(3)) in 7 cases (20.6%), and anemia (<10 gm/dl) in 7 cases (20.6%), respectively. GB hydrops or cholecystitis were noted in 3 cases (8.8%) abnormal ECG finding in 1 case (2.9%), coronary dilatation or aneurysm in 2 cases (5.9%). Liver biopsy was done in four cases and revealed mild infiltration of lymphocytes on the portal area and mild bile duct proliferations. CONCLUSION: The abnormal liver function was noted in 34.7% of KD patients, and subsided all within one month. But the liver function test should be checked closely in patients of the abnormal liver function test complicated with KD despite of its good prognosis.
