Progress in imaging research of neurovascular coupling disorders in Alzheimer's disease
10.3760/cma.j.cn371468-20240918-00428
- VernacularTitle:阿尔茨海默病神经血管耦合障碍的影像学进展
- Author:
Ting LI
1
;
Rongfeng QI
;
Bing ZHANG
Author Information
1. 南京大学医学院附属鼓楼医院医学影像科，南京大学医学影像与人工智能研究所，南京 210008
- Keywords:
Alzheimer's disease;
Neurovascular coupling;
Functional brain imaging;
Cerebral blood flow;
Arterial spin labeling
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(11):1007-1012
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a progressive neurodegenerative disease, and in-depth study of its pathogenesis to enable early diagnosis of the disease, as well as identification of potential therapeutic targets, are the current research priority. Cerebrovascular dysfunction is considered to be an important pathophysiological mechanism in AD. Neurovascular coupling, which serves as a bridge between neural activity and vascular response, has emerged as a new frontier in the study of cerebrovascular dysfunction in AD. It provides a new perspective to reveal the correlation between vascular pathology and AD. This article reviewd and summarized existing research on changes in cerebral blood perfusion and neural electrical activity across the AD continuum, using various imaging techniques to assess neurovascular coupling. The results indicate that compensatory mechanisms in cerebral blood perfusion can be observed in AD using multiple imaging techniques, and reductions in cerebral blood perfusion and neural electrical activity correlate with the deterioration of cognitive function. Neurovascular coupling indicators derived from multimodal imaging demonstrate good sensitivity and specificity in distinguishing healthy individuals from patients with varying degrees of cognitive impairment, holding promise as effective imaging biomarkers for assessing AD.
