Grey matter volume changes and their correlation with anxiety severity in adolescents with major depressive disorder accompanied by anxiety distress specifier
10.3760/cma.j.cn371468-20240626-00297
- VernacularTitle:重度抑郁障碍伴焦虑痛苦青少年灰质体积变化及其与焦虑程度的相关性
- Author:
Rong YANG
1
;
Hongyu ZHENG
;
Xiaomei CAO
;
Daming MO
;
Yue YANG
;
Hui ZHONG
Author Information
1. 安徽医科大学附属心理医院儿童青少年科，合肥 230022
- Keywords:
Gray matter volume;
Anxious distress specifier;
Major depressive disorder;
Adolescent
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(11):974-978
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate grey matter volume changes and their correlation with the severity of anxiety in adolescents with major depressive disorder (MDD) accompanied by anxious distress specifier (ADS).Methods:From June 2022 to June 2023, totally 71 inpatients with MDD in the child and adolescent psychiatry department of Anhui Mental Health Center were included. According to the definition of ADS in the DSM-5, MDD adolescents were divided into the group with anxious distress (MDD/ADS+ group, n=44) and the group without anxious distress (MDD/ADS- group, n=27). Healthy adolescents matched in terms of gender, age, education level were recruited as the control group (HC group, n=19). Voxel-based morphometry (VBM) was used to compare changes in grey matter volume among the three groups.Grey matter volume values of brain regions with significant differences between the MDD/ADS+ group and MDD/ADS- group were collected, and their correlation with Hamilton anxiety rating scale (HAMA) score were analyzed by Pearson correlation analysis using SPSS 26.0 software. Results:Compared to the MDD/ADS- group, the MDD/ADS+ group showed a significant decrease in grey matter volume in the right dorsolateral prefrontal cortex (MNI: x=16.5, y=34.5, z=52.5, t=4.48, P<0.05) and the right cerebellum (MNI: x=49.5, y=-69.0, z=-24.0, t=5.18, P<0.05). In MDD adolescents, the grey matter volumes of the right dorsolateral prefrontal cortex and the right cerebellum were negatively correlated with HAMA score ( r=-0.249, -0.491, both P<0.05). Conclusion:In adolescents with MDD accompanied by ADS, a decrease in gray matter volume is observed in the right dorsolateral prefrontal cortex and the right superior cerebellum. These brain regions may serve as potential biological markers for the severity of anxiety in adolescents with MDD.
