Necroptosis mediated by receptor-interacting serine/threonine-protein kinase 1 and Alzheimer's disease

VernacularTitle:受体相互作用蛋白激酶1介导的细胞程序性坏死与阿尔茨海默病
Author: Yujun QIAO ¹ ; Qin WEI ; Haile CHEN ; Yinliang BAI
Author Information

1. 兰州大学第二医院药剂科，兰州　730030
Keywords: Alzheimer's disease; Necroptosis; Receptor interacting protein kinase 1
From: Chinese Journal of Behavioral Medicine and Brain Science 2024;33(10):955-960
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD) is a refractory neurodegenerative disease clinically characterized by memory loss and cognitive and behavioral dysfunction. The main pathological features of AD include neuronal loss, β-amyloid protein(Aβ) deposition and neurofibrillary tangles (NFTs), and numerous studies have shown that these may be triggered by neuronal death and neuroinflammation Receptor-interacting serine/threonine-protein kinase 1(RIPK1) is a serine/threonine kinase present at the intersection of cell death and inflammatory signaling pathways.Studies in recent years have revealed a potential role of RIPK1 on the progress of AD. In this paper, we summarized the links between RIPK1-mediated necroptosis and AD treatment from the aspects of neuronal death, inflammasome activation, blood-brain barrier breakdown and mitochondrial dysfunction, and the targeted treatment of RIPK1, the new findings of RIPK1 inhibitors and ongoing clinical trials, aiming to provide new ideas for the treatment of AD.