Role of human milk oligosaccharides in childhood neurodevelopment
10.3760/cma.j.cn371468-20240407-00155
- VernacularTitle:人乳寡糖对儿童神经发育的作用
- Author:
Jiamin DONG
1
;
Xinyi YANG
;
Jinling MO
;
Qinfen ZHANG
;
Wenting ZHANG
Author Information
1. 南通大学附属常州儿童医院，儿科中心实验室，常州 213003
- Keywords:
Human milk oligosaccharides;
Neurodevelopment;
Cognition;
Gut-brain axis;
Infants
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(10):920-925
- CountryChina
- Language:Chinese
-
Abstract:
Human milk oligosaccharides (HMOs), as the third most abundant solid nutrient in breast milk, are critical for early infants growth. HMOs are not only involved in the development of the immune system, maintaining inflammation balance, regulating gut microbiota, and participating in the maturation of the digestive system, but also in the improvement of the brain's nervous system and the development of advanced cognitive functions such as learning and memory. However, the role of HMOs in regulating neural development remains unclear. Related studies have focused on the mechanism of the microbiota-gut-brain axis, indicating that there is a practical interaction between the gut and brain. The function of HMOs in children's neurocognition and the biological process of disorders via this mechanism has also been preliminary reported. This review aims to review the structural characteristics and species-specific characteristics of HMOs, and analyze the potential pathways of HMOs in infant nervous system development from the perspective of the microbiota-gut-brain axis.
