Adenosine monophosphate-activated protein kinase and vascular cognitive impairment
10.3760/cma.j.cn371468-20230825-00066
- VernacularTitle:腺苷酸活化蛋白激酶与血管性认知障碍
- Author:
Qianqian QI
1
;
Zhenjie TENG
;
Xiaohua XIE
;
Yanhong DONG
;
Peiyuan LYU
Author Information
1. 河北省人民医院神经内科，河北省脑网络与认知障碍疾病重点实验室，石家庄 050051
- Keywords:
Adenosine monophosphate-activated protein kinase;
Vascular cognitive impairment;
Oxidative stress;
Autophagy;
Neuroinflammation;
Apoptosis
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(6):567-571
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine monophosphate-activated protein kinase(AMPK) is a highly conserved serine/ threonine protein kinase which plays an important role in regulating energy metabolism of the systemic cells. Under stress conditions, such as ischemia and hypoxia, AMPK can be activated.Then it plays a neuroprotective role in regulating mechanisms such as oxidative stress, autophagy, apoptosis and neuroinflammation and so on. Researches have found that chronic cerebral hypoperfusion may be a major cause of vascular cognitive impairment(VCI).AMPK can exert neuroprotective effects on VCI by regulating the aforementioned pathological processes.Therefore, this article reviews the molecular biological characteristics of AMPK and its role and mechanism in VCI, with the aim of promoting further research on AMPK and making it a new target for VCI treatment.
