Establishment and evaluation of rodent animal model of adolescent depression
10.3760/cma.j.cn371468-20230725-00018
- VernacularTitle:青春期抑郁啮齿类动物模型的建立与评价
- Author:
Tao DONG
1
;
Ying LI
;
Yao GAO
;
Penghong LIU
;
Zhifen LIU
Author Information
1. 山西医科大学第一临床医学院，太原 030604
- Keywords:
Adolescence;
Depression;
Animal model;
Model establishment
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(6):560-566
- CountryChina
- Language:Chinese
-
Abstract:
Depression is one of the most common mental disorders in adolescents, with high recurrence rate and high suicide rate, seriously endangering the physical and mental health development of adolescents. Adolescent depression animal models can mimic the human depression phenotype, which can help to study the disease pathogenesis, find effective therapeutic targets, and develop new antidepressant drugs. Therefore, in order to screen animal models that better meet the experimental requirements, this paper reviews the articles on animal models of adolescent depression, comprehensively summarises and analyses the modelling methods and principles, strengths and weaknesses, and behavioural evaluations of the commonly used animal models of adolescent depression (stress models, genetic models, chemically-induced models, surgical injury models and composite models), and look forward to the development direction of animal models of depression in adolescence. It also looks forward to the development direction of adolescent depression animal models, aiming to better simulate the development of the disease, provide a variety of animal models for adolescent depression animal model related research, and lay the foundation for subsequent research.
