Application of chemogenetic technology in the study of neural circuits in depression
10.3760/cma.j.cn371468-20230810-00048
- VernacularTitle:化学遗传学技术在抑郁症神经环路研究中的应用
- Author:
Shaowei LI
1
;
Jiehui LI
;
Mingkuan ZHANG
;
Hao ZHANG
;
Minghui HU
;
Dan CHEN
;
Kaiyong XU
;
Zifa LI
;
Xiwen GENG
;
Sheng WEI
Author Information
1. 山东中医药大学中医学院，济南 250355
- Keywords:
Chemogenetic technology;
Neural circuit;
Depression;
Neuroregulation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(6):554-559
- CountryChina
- Language:Chinese
-
Abstract:
Chemogenetic technology is a receptor-ligand system that regulates cell viability and function by changing receptor specificity and affinity, and it achieves precise neuronal regulation by specifically regulating neurons and neural circuits. At present, this technique is widely used in the study of neural circuits. This article briefly describes the application and progress of chemogenetic technology in the study of depression neural circuits, reviews the application of chemogenetic technology in several brain regions closely related to depression, such as ventral tegmental area, nucleus accumbens, prefrontal cortex, hippocampus and lateral habenula, and discusses the potential and challenges of chemogenetic technology as a technology for precise regulation of neural activity in future research, in order to provide reliable ideas and directions for chemogenetic technology in the study of depression neural circuits.
