circular RNA and cognitive dysfunction related diseases
10.3760/cma.j.cn371468-20230227-00100
- VernacularTitle:环状RNA与认知功能障碍相关疾病
- Author:
Shuqi LIU
1
;
Xinyu WU
;
Jiabin LIN
;
Shengming YIN
Author Information
1. 大连医科大学基础医学院，大连 116044
- Keywords:
Circular RNA;
Micro RNA;
Cognitive function;
Cognitive dysfunction;
Molecular biomarker
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(5):470-474
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA (circRNA) is widely expressed in eukaryotes. Abnormal expression of specific circRNA was found in both animal models with cognitive decline and patients with cognitive dysfunction.However, the role of circRNA in cognitive dysfunction related diseases is still unclear. By introducing the expression of circRNA in cognitive function related brain regions and its impact on brain structure and function, as well as the relevant research progress on the pathological mechanism of circRNA involvement in cognitive dysfunction related diseases, this review provides theoretical basis for revealing the pathological mechanism of circRNA in cognitive dysfunction related diseases and discovering specific circRNA targets for preventing and treating cognitive dysfunction.
