The correlation between amplitude of low frequency fluctuation of spontaneous brain activity in resting-state and cognitive fusion in patients with major depressive disorder
10.3760/cma.j.cn371468-20230919-00122
- VernacularTitle:抑郁症患者静息态自发脑区活动低频振幅与认知融合相关性
- Author:
Xiao DONG
1
;
Huichang QIAN
;
Xiaoman CHENG
;
Xiaozheng LIU
;
Jiehua MA
;
Dandan LIU
;
Jian LIU
Author Information
1. 安徽医科大学精神卫生与心理科学学院，合肥 230032
- Keywords:
Major depressive disorder;
Resting-state magnetic resonance imaging;
Cognitive fusion;
Amplitude of low frequency fluctuation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(5):406-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Based on the pathological model of acceptance and commitment therapy(ACT), to explore the correlation between cognitive fusion and resting-state spontaneous brain activity amplitude of low frequency fluctuation in patients with major depressive disorder(MDD).Methods:Patients with MDD ( n=19) and healthy controls (HCs, n=19)matched with gender, age, and years of education were enrolled from August 2022 to May 2023 in Hangzhou Seventh People's Hospital. 17-item Hamilton depression rating scale(HAMD-17) and cognitive fusion questionnaire(CFQ) were used to estimate the depressive symptoms and cognitive fusion of the participants. The amplitude of low frequency fluctuation(ALFF) data were collected on a 1.5 T-GE scanner. Based on DPABI v7.0 software of MATLAB 7.11.0 (R2018b), two independent sample t-test was used to compare the ALFF of the MDD group and HC group. ALFF values and the cognitive fusion scale scores were investigated by Pearson correlation analysis. Results:Compared with HCs, ALFF in patients with MDD was decreased relatively in the left triangular part of the inferior frontal gyrus(MNI: x, y, z=-36, 24, 21; t=-2.107, P=0.042), the right cuneus(CUN; MNI: x, y, z=12, -87, 24; t=-8.635, P<0.001) as well as the left calcarine fissure and surrounding cortex(MNI: x, y, z=-18, -57, 6; t=-14.188, P<0.001), while increased relatively in left superior occipital gyrus(MNI: x, y, z=-21, -72, 33; t=-7.253, P<0.001). There was a significant negative correlation between cognitive fusion and ALFF values of abnormal activity in left IFGtriang (belonging to ECN)( r=-0.57, P<0.05). Conclusion:There is a correlation between cognitive fusion and resting-state spontaneous brain activity ALFF in patients with MDD. Both cognitive fusion and depressive symptoms may affect patients' cognitive control deficits through multiple sources.
