A functional magnetic resonance imaging study on correlation between dynamic amplitude of low frequency fluctuation and spatial navigation impairment in individuals with subjective cognitive decline
10.3760/cma.j.cn371468-20231031-00186
- VernacularTitle:主观认知下降人群动态低频振幅与空间导航障碍相关性的功能磁共振成像研究
- Author:
Futao CHEN
1
;
Cong LONG
;
Qian CHEN
;
Yajing ZHU
;
Xin ZHANG
;
Jiu CHEN
;
Jiaming LU
;
Bing ZHANG
Author Information
1. 南京大学医学院附属鼓楼医院医学影像科，南京 210008
- Keywords:
Subjective cognitive decline;
Functional magnetic resonance imaging;
Spatial navigation;
Amplitude of low frequency fluctuation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(5):385-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the differences in dynamic spontaneous brain activity in individuals with subjective cognitive decline (SCD) and its correlation with spatial navigation ability in SCD subjects.Methods:A total of 72 SCD subjects(SCD group) and 67 normal controls (NC group) matched for age, gender and education level were recruited from September 2020 to February 2023 at the Affiliated Drum Tower Hospital, Medical School of Nanjing University. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) examinations, spatial navigation tests and cognitive function assessments. The rs-fMRI time series were segmented using a sliding time window method, and statistical analyses were carried out using SPSS 26.0 software to compare the differences in the dynamic amplitude of low frequency fluctuation (dALFF) between the two groups. Correlation analysis was conducted between dALFF values in different brain regions and scale scores and spatial navigation tests.Results:Compared with the NC group, the dALFF variability in the right precuneus(0.119±0.021, 0.130±0.031) and left cuneus(0.143±0.034, 0.156±0.032) in SCD group decreased ( t=-3.41, -3.12, P<0.05, FDR corrected), and the dALFF variability in the right middle occipital gyrus(0.146±0.023, 0.137±0.020) and right angular gyrus(0.148±0.025, 0.139±0.026) increased ( t=4.51, 3.36, both P<0.05, FDR corrected). The temporal variability of dALFF in the right precuneus in SCD group was negatively correlated with egocentric spatial navigation ( r=-0.341, P=0.025), delayed allocentric spatial navigation ( r=-0.286, P=0.035) and memory function ( r=-0.332, P=0.009). The temporal variability of dALFF in the left middle occipital gyrus was positively correlated with language function ( r=0.339, P=0.015) and visuospatial function ( r=0.343, P=0.008) in SCD group. Conclusions:The temporal variability of dALFF in the right precuneus and the left middle occipital gyrus may be the neurobiological basis of cognitive decline and spatial navigation impairment in SCD subjects, and it can be used as a potential imaging marker for early identification of SCD patients.
