Meta-analysis of θ short array rapid pulse stimulation in treatment of schizophrenia
10.3969/j.issn.1000-6729.2024.10.003
- VernacularTitle:θ短阵快速脉冲刺激治疗精神分裂症的meta分析
- Author:
Yan LI
1
;
Lei YAN
;
Jie Yong LI
;
Yuan XIA
;
Zhen LIANG
;
Hailan TANG
;
Jialin GUO
;
Zhu WANG
Author Information
1. 武汉体育学院运动医学院,武汉 430000
- Keywords:
schizophrenia;
θ Short array fast pulse stimulation;
meta-analysis
- From:
Chinese Mental Health Journal
2024;38(10):846-853
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of θ short burst rapid pulse stimulation(TBS)in treating schizophrenia by meta-analysis.Methods:Randomized controlled trials(RCTS)on TBS in the treatment of schizophrenia were searched from CNKI,Wanfang,VIP,China Biomedicine,Web of science,PubMed,Embase and Cochrane Library databases to December 2022.The main study indicator was the Positive and Negative Symptoms Scale(PANSS).Risk quality assessment of the included literatures was performed by two reviewers and statistical analysis was performed using RevMan5.3.Results:A total of 13 RCTS with 641 patients were included.Meta-anal-ysis showed that TBS targeting the left dorsolateral prefrontal cortex(DLPFC)with intervention duration longer than 2 weeks decreased the PANSS total scores(WMD=-4.63,95％CI:-5.75--3.51,P＜0.001),positive symptom scores(WMD=-1.13,95％CI:-2.00--0.26,P＜0.05),negative symptom scores(WMD=-2.51,95％CI:-2.77--1.53,P＜0.001)and general psychopathological symptom scores(WMD=-1.20,95％CI:-1.80--0.60,P＜0.001).The adverse reactions of TBS included dizziness,and no serious adverse e-vents were reported.Conclusion:TBS has high safety,and stimulation of left dorsolateral prefrontal cortex targets for more than 2 weeks could effectively improve psychiatric symptoms in patients with schizophrenia.
