Relationship between white matter microstructural features and cognitive function in patients with bipolar disorder
10.3969/j.issn.1000-6729.2024.10.001
- VernacularTitle:双相障碍患者白质微结构特征与认知功能的关系
- Author:
Junfan LIANG
1
,
2
;
Hua LIU
;
Xinyin GUO
;
Xuehua LI
;
Jixiang YUAN
;
Minglan YU
;
Tingting WANG
;
Rongfang HE
;
Bo XIANG
;
Kezhi LIU
;
Xuemei LIANG
Author Information
1. 西南医科大学附属医院精神科,四川泸州 646000
2. 精神疾病基础与临床泸州市重点实验室,四川泸州 646000
- Keywords:
bipolar disorder;
diffusion tensor imaging;
white matter;
cognitive function
- From:
Chinese Mental Health Journal
2024;38(10):833-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the white matter structural characteristics in patients with bipolar disorder(BD)using diffusion tensor imaging(DTI)and investigate their relationship with cognitive function.Methods:A total of 15 patients with BD type Ⅰ and 26 patients with BD type Ⅱ who met the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-Ⅳ)diagnostic criteria and 37 normal controls were included.Cognitive function was assessed with the Trail Making Test(TMT)and Repeatable Battery for the Assessment of Neuropsy-chological Status(RBANS).The tract-based spatial statistics(TBSS)method was used to explore the differences in fractional anisotropy(FA)and mean diffusivity(MD)among the three groups and perform correlation analyses with cognitive function.Results:Patients with BD Ⅰ and BD Ⅱ had lower scores in attention(P＜0.001),delayed memory(P＜0.01),and total scores(P＜0.001)on the RBANS compared to the normal control group.They also exhibited lower FA values in the corpus callosum and right superior corona radiata compared to the normal control group(P＜0.05).In the BD Ⅰ group,there was a positive correlation between FA values in the genu of corpus cal-losum and visuospatial/constructional scores(r=0.74,P＜0.05),while in the BD Ⅱ group,a positive correlation was found between FA values in the same region and language function scores(r=0.55,P＜0.05).Conclusion:It suggests that patients with bipolar disorder may have impaired white matter integrity in the corpus callosum and right superior corona radiata,which may be associated with cognitive impairment.
