A meta-analysis of effects of repetitive transcranial magnetic stimulation on cognitive function intervention in patients with schizophrenia
10.3969/j.issn.1000-6729.2024.09.002
- VernacularTitle:重复经颅磁刺激对精神分裂症患者认知功能干预效果的meta分析
- Author:
Fen YU
1
;
Shuqi JIA
;
Peng WANG
;
Shufan LI
;
Xing WANG
Author Information
1. 上海体育大学,上海 200438
- Keywords:
repetitive transcranial magnetic stimulation;
schizophrenia;
cognition;
meta-analysis
- From:
Chinese Mental Health Journal
2024;38(9):745-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the intervention effects of repetitive transcranial magnetic stimulation on cognitive function of schizophrenia patients with methods using meta-analysis.Methods:CNKI,Wanfang Data,VIP,PubMed,Web of Science,the Cochrane Library and Embase were searched for randomized controlled trials of repetitive transcranial magnetic stimulation on cognitive function in schizophrenia.Quality assessment was per-formed with the Cochrane Handbook for Systematic Reviews.Effect sizes and heterogeneity were assessed using RevMan 5.3.Results:A total of 31 randomized controlled trials(2 421 patients)were included in this study.Meta-analysis showed that rTMS improved cognitive function in schizophrenia patients(SMD=0.73).Subgroup analyses showed that intervention intensity was less than or equal to 100％RMT,the intervention frequency was 1 Hz,the intervention time was lasted at least 20 min/time,and the intervention period was four weeks,the effect of rTMS was better.Subgroup analyses showed that rTMS was more effective in improving for patients with durations of 5 to 10 years.Conclusion:rTMS has more significant improvement effects on cognitive function in schizophrenia pa-tients.It is recommended to set the intervention intensity 100％RMT,the intervention frequency of 1 Hz,the in-tervention time ≥20 min,and the intervention period of 4 weeks in the clinic.
