A 5-year follow-up study of effects of combined electroconvulsive therapy on relapse and cognitive function in patients with major depressive disorder
10.3969/j.issn.1000-6729.2024.08.001
- VernacularTitle:联合电休克治疗对抑郁症患者复发及认知功能影响的5年随访研究
- Author:
Jiao YAO
1
,
2
;
Kangjian XU
;
Yue GAO
;
Yang DU
;
Xiaotong XU
;
Yueqin HUANG
;
Yifu JI
Author Information
1. 安徽医科大学精神卫生与心理科学学院,合肥 230032
2. 安徽医科大学附属心理医院安徽省精神卫生中心 合肥市第四人民医院,合肥 230032
- Keywords:
major depressive disorder;
electroconvulsive therapy;
cognitive function;
relapse
- From:
Chinese Mental Health Journal
2024;38(8):641-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of modified electroconvulsive therapy(MECT)in combina-tion with medication and medication alone on relapse and cognitive functioning in patients with major depressive disorder(MDD).Methods:Totally 324 patients meeting the diagnostic criteria ofthe DSM-5 for MDD were select-ed and divided into combined MECT group(n=117)and non-combined MECT group(n=207).At baseline and 5 years of follow-up,both groups completed the General Information Questionnaire,Montreal Cognitive Assessment(MoCA),and Hamilton Depression Scale(HAMD)to analyze associations between cognitive functioning and mul-tiple variables.Results:At baseline,there were no significant differences between the two groups on general infor-mation,MoCA,and HAMD scores(Ps＞0.05).After 5 years of follow-up,the relapse rate was lower in the com-bined MECT group than in the un-combined MECT group[(37.6％vs.72.0％),P＜0.001].MECT was a protec-tive factor against recurrence of MDD[RR(95％CI)=0.52(0.40-0.66)],and the MoCA scores were lower in the combined MECT group than in the un-combined MECT group[(20.9±3.5)vs.(23.6±4.2),β=-1.93,P＜0.001].Conclusion:Combined MECT is a protective factor against MDD recurrence.Its effects on the cognitive functioning of MDD patients may have long-term effects.
