Dynamic functional connectivity and effective connectivity of postcentral gyrus in patients with schizophrenia
10.3969/j.issn.1000-6729.2024.07.006
- VernacularTitle:精神分裂症患者动态功能连接和效应连接的功能磁共振成像研究
- Author:
Wenjuan LIU
1
;
Weiliang YANG
;
Shimin YE
;
Huiming NIU
;
Yiqiong JIN
;
Gang LI
;
Gangping WANG
;
Ning HOU
;
Jie LI
Author Information
1. 天水市第三人民医院,甘肃天水 741000
- Keywords:
schizophrenia;
dynamic regional homogeneity;
dynamic functional connectivity;
granger causal-ity analysis
- From:
Chinese Mental Health Journal
2024;38(7):585-590
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics of brain dynamic activity in patients with schizophrenia by using functional magnetic resonance imaging(fMRI).Methods:Forty-three patients with schizophrenia and 31 normal controls were recruited and under fMRI scanning.The Positive and Negative Symptom Scale(PANS)was used to assess the severity of clinical symptoms.The DPABI software were used to compute dReHo and dFC.Granger causality analysis was used to calculate the effective connectivity between the significant brain regions of dReHo and the whole brain.Two sample t-test was performed to compare the difference of dReHo and dFC be-tween patients with schizophrenia and normal controls.Results:The dReHo of left postcentral gyrus(LPG)(P＜0.01,cluster-level FWE corrected)in patients with schizophrenia was decreased.The Dfc was increased between left postcentral and left middle frontal gyrus,left superior medial frontal gyrus,right calcarine,left medial cingulum gyrus,right supplementary motor area(P＜0.01,uncorrected).Compared with normal controls,patients with schiz-ophrenia showed decreased effective connectivity from LPG to right putamen.Conclusion:It suggests that the ab-normal functional activity of the postcentral gyrus mightcontribute to the neural physiopathology in patients with schizophrenia.
