Evaluation of Coronary Microcirculatory Function in Patients With Hypertrophic Cardiomyopathy and Analysis of Preliminary Results
10.3969/j.issn.1000-3614.2024.10.005
- VernacularTitle:肥厚型心肌病患者冠状动脉微循环功能的评价及初步分析
- Author:
Haobo XU
1
;
Fasheng ZHU
;
Weixian YANG
;
Jiansong YUAN
;
Juan WANG
;
Tianjie WANG
;
Yilu LIU
;
Yong WANG
;
Tao TIAN
;
Shubin QIAO
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 冠心病中心,北京 100037
- Keywords:
hypertrophic cardiomyopathy;
coronary microcirculatory dysfunction;
index of microcirculatory resistance
- From:
Chinese Circulation Journal
2024;39(10):983-988
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To evaluate the coronary microcirculatory function in patients with hypertrophic cardiomyopathy(HCM). Methods:Patients who diagnosed with HCM and underwent the measurement of index of microcirculatory resistance(IMR)using pressure-sensing guide wire from November 2021 to April 2023 were prospectively included.Coronary microcirculatory dysfunction(CMD)was defined as IMR≥25 U and patients were grouped accordingly to compare the clinical characteristics. Results:A total of 25 HCM patients were included.Mean age was(58.4±13.3)years,18 were men and mean body mass index was(26.7±3.6)kg/m2.Coronary microcirculatory function was successfully evaluated in all patients and the mean value of IMR was(30.5±15.3)U.There were 15 patients with CMD.Baseline clinical characteristics,laboratory examinations and medications were simialr between patients with and without CMD.The maximal left ventricular wall was significant thicker in patients with CMD compared with that in patients without CMD([20.2±2.8]mm vs.[16.9±2.3]mm,P=0.005).There was no significant difference in other echocardiographic parameters between two groups(all P>0.05).In the range of IMR value less than 50 U(n=22),there was a significant linear positive correlation between maximal left ventricular wall thickness and IMR(r=0.423,P=0.049).There was no significant difference in coronary flow reserve and fractional flow reserve between two groups. Conclusions:The severity of CMD is positively correlated with left ventricular wall thickness in HCM patients.
