Association Between Cumulative Fasting Blood Glucose and Coronary Artery Calcification
10.3969/j.issn.1000-3614.2024.05.003
- VernacularTitle:累积空腹血糖水平与冠状动脉钙化的关联
- Author:
Chenyang LI
1
;
Fangchao LIU
;
Shufeng CHEN
;
Jianxin LI
;
Jie CAO
;
Keyong HUANG
;
Liancheng ZHAO
;
Ying LI
;
Jianfeng HUANG
;
Bin LYU
;
Xiangfeng LU
;
Dongfeng GU
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 心血管流行病学重点实验室 流行病研究部,北京 102300
- Keywords:
cumulative fasting blood glucose;
coronary artery calcification;
coronary artery calcification score;
risk factor
- From:
Chinese Circulation Journal
2024;39(5):444-450
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:This study aims to investigate the association between cumulative fasting blood glucose(FBG)and presence of coronary artery calcification(CAC). Methods:A total of 1 113 participants were recruited from the Beijing Community-based Cohort of Atherosclerosis.Anthropometric measurements and laboratory examinations including FBG were performed in 1998,2008-2009 and 2013-2014 respectively,and coronary CT scan was performed in 2013-2014.Participants were classified into 4 groups according to the level of cumulative FBG(10-year weighted cumulative value of at least 2 FBGs):<50.0 mmol/L group(n=495),50.0-55.9 mmol/L group(n=345),56.0-69.9 mmol/L group(n=176),and≥70.0 mmol/L group(n=97).CAC score>0 was defined as presence of CAC.Multivariable logistic regression model was applied to analyze the impact of cumulative FBG exposure on the risk of CAC,and subgroup analyses were conducted according to factors such as sex and age. Results:The mean age of enrolled participants was(59.7±6.4)years,523(47.0%)were male and 478(42.9%)had CAC.The proportion of subjects with CAC increased with the increment of cumulative FBG.Compared with the<50.0 mmol/L group,the multivariable-adjusted OR(95%CI)for CAC in the 50.0-55.9 mmol/L group,56.0-69.9 mmol/L group,and≥70.0 mmol/L group were 1.43(1.04-1.98),1.92(1.24-2.99)and 2.79(1.35-5.77),respectively(Ptrend<0.05).The risk for CAC increased by 34%per 10 mmol/L increase in cumulative FBG,with OR(95%CI)of 1.34(1.12-1.59).There was no statistically significant difference in the risk of CAC presence for each 10 mmol/L increase in cumulative FBG level between the subgroups(all P≥0.05). Conclusions:Elevated cumulative FBG is a risk factor for the prevalence of CAC,indicating the importance of maintaining healthy FBG in preventing the occurrence of CAC.
