Efficient Synthetic Method of 1,2-substituted benzimidazoles
10.3969/j.issn.1007-7693.2008.03.013
- VernacularTitle:1,2二取代苯并咪唑化合物的一种高效合成方法
- Author:
Hui ZHAO
1
;
Ya-Mu XIA
;
Pan-Ming JIAN
Author Information
1. 兰州大学附属第二医院
- Keywords:
benzimidazole;
dischiff base;
1，3 shift
- From:
Chinese Journal of Modern Applied Pharmacy
2008;25(3):209-210
- CountryChina
- Language:Chinese
-
Abstract:
The benzimidazole exhibits widespread activities,and the benzimidazole nucleus is found in a variety of drugs. In this paper,we research a new and efficient synthetic method of 1,2-disubstituted benzimidazole. o-phenylenediamine and ketone form schiff bases having one free amine group with microwave,and then schiff bases condensed with different aldehydes to give five 1,2-substituted benzimidazoles.The mechanism of reaction involves 1,3 shift of negative hydrogen ion.
