Determination of Nimesulide in Suppositories by UV
10.3969/j.issn.1007-7693.2007.02.027
- VernacularTitle:紫外分光光度法测定尼美舒利栓中尼美舒利含量
- Author:
Xin-Mei CHEN
1
Author Information
1. 山东中医药大学
- Keywords:
Nimesulide Suppositories;
UV;
Determination
- From:
Chinese Journal of Modern Applied Pharmacy
2007;24(2):151-153
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To establish a method for determination of Nimesulide in suppositories. METHODS Screening different organic solvent to extract 36 type semi-sythetic fatty acid ester in suppositories and determinating Nimesulide by UV. RESULTS N-Hexano was used as the solution of extraction. A good linearity was within the concentration range of 3～15μg/mL with a Borrelation coefficient of 0.9999. The average recovery was 98.3%. The RSD for reproducibility was 0.47%. CONCLUSION The method is simple, accurate and reliable.
