Determination of loratadine in human plasma by HPLC with solid phase extraction method
10.3969/j.issn.1007-7693.2006.02.017
- VernacularTitle:固相萃取-高效液相色谱法测定氯雷他定的血药浓度
- Author:
Gang LIU
1
;
Hui WANG
;
Ben-Hong ZHOU
;
Xian-Zhou ZHANG
;
Jia-Chuan LEI
Author Information
1. 武汉大学附属人民医院(湖北省人民医院)
- Keywords:
HPLC;
loratadine;
drug concentration in plasma
- From:
Chinese Journal of Modern Applied Pharmacy
2006;23(2):134-136
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To establish a method for the determination of loratadine in human plasma using a solid-phase extraction and reversed-phase HPLC. METHODS The sample was treated with ODS-C18 solid-phase extraction column, Zorbax SB-C18 columnthe relative standard deviations of within-day and between-day were less than 10%. The minimal detectable concentration in plasma plasma. It was suitable for the pharmacokinetics and bioavailability study of Loratadine.
