Protective effects of Qishen capsule on experimental focal cerebral ischemia in rats

VernacularTitle:芪参胶囊对大鼠局灶性脑缺血再灌注损伤的保护作用
Author: Song-Qiang XIE ¹ ; Guo-Qiang HU ; Zhong-Quan ZHANG ; Bian-Sheng JI ; Guang HAN ; Qin LI ; Qi-Tai XU
Author Information

1. 河南大学
Keywords: Qishen capsule; nitric oxide synthase; intracellular free calcium; Ca2+-ATPase; Na +; K+-ATPase; cerebral ischemia; focal
From: Chinese Journal of Modern Applied Pharmacy 2006;23(1):9-13
CountryChina
Language:Chinese
Abstract: OBJECTIVE To study the effects of Qishen capsule against focal cerebral ischemia reperfusion injury in rats.METHODS The rat model of focal cerebral ischemia-reperfusion was established with the middle cerebral artery occlusion (MCAO)by reversible inserting a nylon thread method. Rats were killed after ischemia 1 hour and reperfusion 2 hours. Brain were fetched out and measured the contents of H2 O, [ Ca2 + ] i, NO, neurological function evaluation and infarct volume and the activities of NOS,Ca2+ -ATPase, Na+ , K+- ATPase. The sections were stained with hemotoxylin-eosin(HE) or TTC, histological changes of brain were observed. RESULTS Compared with sham operation group, H2 0 and [ Ca2 + ] i, NO contents were lower significantly and the activity Qishen capsule has protective effects on cerebral ischemia-reperfusion lesion.