Evidence-based protection medicine therapy of brain injured patients
10.3969/j.issn.1007-7693.2005.z2.034
- VernacularTitle:循证护保性药物治疗颅脑损伤
- Author:
Dao-Pei LI
1
;
Da-Shang LIN
Author Information
1. xiaolang people hospital
- Keywords:
evidence-based medicine;
brain injure;
protection medicine treatment
- From:
Chinese Journal of Modern Applied Pharmacy
2005;22(z2):760-764
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Reviews the domestic and foreign protection medicine treatment brain to injure the patient foresightedness stochastic double blind clinical research, for soon develops the similar province scientific research to set up a topic to prepare. METHODS Draws support specialized database: Cochrane in library homepage RCT database (E-maail:Injuries@shtm.Ac.Uk), wanfang databases digitization periodical, Qinghuatongfang CHKD periodical entire library. In the comparison, the induction carries on the analysis with in the extract related content foundation. RESULTS Collects overseas to has completed with the medicine treatment brain injure medicine treatment related system appraises 6; domestic related memoir 3, translation 3, special course 6. Domestic related memoir demonstration, The hydrochloride naloxone, the magnesium ion, the glycerol and fructose and so on injure the patient to the brain to be effective; But overseas has completed in more than 200 clinical multi- central stochastic double blind foresightedness research, The unusual medicine was confirmed injures the patient to the brain to have the affirmation the curative effect. CONCLUSION Some many factors disturbance clinical research effect. Improves this kind of research the methodology is removes the disturbance factor the effective method. Must observe the principle below this kind of clinical research process:(1) Must be the stochastic double blind foresightedness clinical research;(2) The clinical treatment must standardize;(3) Collects the clinical material to have objective to be strict;(4) Is clear about the medicine effective treatment window;(5) Is clear about the medicine to organize the Chinese native medicine density and the security in sickness human brain;(6) GOS ( Glasgow Outcome Scale) to take the curative effect judgment primary standard;(7) Wound latter 6 months achievement curative effect judgment time.
