Application of reduced glutathione in the elderly with hepatic dysfunction induced by acute exacerbation of chronic cor pulmonale
10.3969/j.issn.1007-7693.2005.02.011
- VernacularTitle:还原型谷胱甘肽在老年慢性肺心病急性加重期肝损害患者中的应用
- Author:
Shu LEI
1
;
Yang-Chun WU
;
Lin-Cong WANG
;
Jian-Nong WU
;
Xiao-Wen GUO
Author Information
1. 浙江省中医医院
- Keywords:
reduced glutathione (GSH);
chronic cor pulmonale;
hepatic dysfunction
- From:
Chinese Journal of Modern Applied Pharmacy
2005;22(2):118-122
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effect of reduced glutathione (GSH) on the hepatic dysfunction induced by acute exacerbation of chronic cor pulmonale in the elderly. METHOD A total of 66 patients aged 60 years or older with hepatic dysfunction following acute exacerbation of chronic cor pulmonale were randomly divided into 2 groups. All patients received conventional basic therapy for acute exacerbation of chronic cor pulmonale. The control group (n = 31 ) received intravenous inosine 1.0g, vitamin C 2.0g, and kali magnesii aspartatis 20mL once daily for 2 weeks. The GSH group (n = 35) received intravenous GSH 1.2g ql2h for 2weeks. The protective effect against hepatic damage was evaluated by measuring alanine aminotransferase ( ALT), aspartate transaminase (AST), total bilirubin (TBIL), total bile acid (TBA), albumin (ALB), prothrombin time (PT) and child-pugh score at admission and after treatment. RESULTS The GSH group was superior to the control group in the improvements of hepatic function and symptom. The improvements of ALT, AST, TBIL, TBA and child-pugh score in the GSH group were significantly better than those in the control group (P ＜ 0.01 ). The 30-day incidence of acute renal failure in the GSH grup was lower than that in the control group (P ＜ 0.05). There were no statistical differences in the ALB, PT, mortality at discharge and 30-day incidence of multiple organ dysfunction syndrome (MODS) between the 2 groups (P ＞ 0.05 ). CONCLUSION GSH is an effective and safe treatment for hepatic dysfunction induced by acute exacerbation of chronic cor pulmonale in the elderly. The efficacy of GSH is superior to that of conventional treatment for hepatic dysfunction on the basis of controlling infection, improving hypoxemia and hypercapnia and treating the right heart failure.
