Clinical Evalulation of Antihypertensive Efficacy and Safety of Adminis tration of Doxazosin Mesylate in Mild to Moderate Essential Hypertension
10.3969/j.issn.1007-7693.2001.02.029
- VernacularTitle:甲磺酸多沙唑嗪治疗轻、中度高血压的临床疗效及安全性评价
- Author:
Feng LING
1
;
Peizhang LI
;
Guosong QIU
;
Hui MA
;
Minmin HONG
;
Anna GUO
Author Information
1. 浙江省杭州市第一人民医院
- From:
Chinese Journal of Modern Applied Pharmacy
2001;18(2):139-142
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To evaluate the efficacy and safety of admi nistration of doxazosin mesylate in mild to moderate essential hypertension.METHODS In the trial,43 patients meeting the creteria of enlistment after 2-week wash-out periods are randomized into two groups in term of double- blind manner,22 cases for doxazosin mesylate group,21 cases for Terazosin hydroc hloride group.The patients will recept the scheduled medication intervention and blood pressure measure in order to assess the efficacy of antihypertension.Phys ical examnation, electrocardiogram,hematological and urinary test will be perfor med for monitoring the adverse events according to the trial protocol.RE SULTS：The rate of effectiveness of doxazosin mesylate for hypertension controling is 86.4%.No severe adverse events such as the cardiovascular disorder s appear in the 6-week trial except for the mild,toleratable headache in one pat ient.Doxazosin mesylate does not interfere with the hepatic and renal metabolism and impair their functions.CONCLUSIONS：Doxazosin mesylate adim inistration is effective and safe in mild to moderate essential hypertension.
