Determination of aceclofenac in extended-released tablets by HPLC
10.3969/j.issn.1007-7693.2001.01.027
- VernacularTitle:高效液相色谱法测定醋氯芬酸缓释片的含量
- Author:
Huaiwu WANG
1
;
Li HUANG
;
Zhinan MEI
Author Information
1. Huangshi Traditional Pharmacy Co.LTD
- From:
Chinese Journal of Modern Applied Pharmacy
2001;18(1):53-55
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To establish a HPLC method for the determine of aceclofenac extended tablets.METHODS:A Zorbax SB-C18 column was used.The mobile phase was acetonitrile-tetrahydrofuran-glacial acetic acid(25∶25∶50,adjusted to pH 3.5 with 1.0 mol/L NaOH) and the flow rate was 1.0ml/min,intertal standard was para-hydroxybiphenyl.The UV detection wavelength was 275nm.RESULTS:The calibration curve was linear in the range from 10.2μg/ml to 50.1μg/ml(r=0.9993) and the average recovey was 100.3%(RSD=0.45%).CONCLUSION:The method is selective,simple and accurate.
