Improved synthesis of diphenoxylate hydrochloride
10.3969/j.issn.1007-7693.2001.01.022
- VernacularTitle:苯乙哌啶合成的改进
- Author:
B LIU
1
;
Xinglian YAN
;
Haiting HU
Author Information
1. Kaifeng Medical College
- From:
Chinese Journal of Modern Applied Pharmacy
2001;18(1):46-47
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：Improve the synthetic method of diphenoxylate hydrochloride,which was more suitable for the industrial process.METHOD:N,N-bis(β-chloroethyl)-4-methyl phenyl sulfonylamine was used as starting material vialiquid-liquid phase transfer catalysis to prepare 1-(4-methyl phenyl)-sulfonyl-4-phenyl-4-piperidine cabonitrile,which by hydrolysis,esterification,condensation,salifying to yield diphenoxylate hydrochloride.RESULTS:The total yield ammounted to 51.8%.CONCLUSION:The method was suible for the industrial process.
