Synthesis of Tacrine
10.3969/j.issn.1007-7693.2001.01.020
- VernacularTitle:他克林的合成研究
- Author:
Huibin ZHANG
1
;
Jinpei ZHOU
;
Wenlong HUANG
Author Information
1. China Pharmaceutical University
- From:
Chinese Journal of Modern Applied Pharmacy
2001;18(1):44-45
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To synthesize Tacrine,a new drug for the treatment of Alzheimer′s disease.METHOD:With the 2-aminobenzoic acid as the starting material，Tacring was synthesized via condensation-cyclization,chlorization and amination.RESULTS:Each step was modified and improved.The overall yields was 40.7%.The melting point and IR、1HNMR of the product prepared were identical as that of the reportedone.CONCLUSION:The process can be easily controled and is suitable for a scale production.
