Effect of 1,6-Fructose diphosphate capules on animal cerebral is chemia

VernacularTitle:果糖二磷酸钠对动物急性脑缺血的保护作用
Author: Weijun LIU ¹ ; Haisong CHEN ; Chunqing XU
Author Information

1. Hainan Institute
Keywords: 1,6-Fructose Diphosphate(FDP),anoxia,cerebral ischemia,protective effects
From: Chinese Journal of Modern Applied Pharmacy 2000;17(3):171-174
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To inves tigate the therapeutic effects of 1,6-fructose diphosphate(FDP) in mice and rat s which were in the induced states of anoxia and acute cerebral ischemia.M ETHODS:Anoxia was induced in mice with a closed normobaric hypoxia chamber .The clinical condition of acute cerebral ischemia was simulated in mice and rat s by decollating and ligating both carotid arteries.FDP was given intragastrical ly in all tests.RESULTS:Intragastric FDP markedly prolonged the surv ival time of mice which were in the induced states of anoxia and acute cerebral ischemia. Intragastric FDP markedly decreased the WBR(wet wt of brain/body wt×1 00) and water weight of brain and inhibited the rise of serum CK in rats with ac ute cerebral ischemia.Intragastric FDP also improved the capacity of blood passi ng through the blood vessel. There was a change in serum LDH,but it was not sign ificant.CONCLUSION:FDP has therapeutic effects in mice and rats to c ounteract the tissue damage caused by the experimentally induced states of anoxi a and cerebral ischemia.