Effects of integrin αvβ6 on lipidomics metabolism in relation to tumor progression for colon cancer
10.3969/j.issn.1009-9905.2024.09.002
- VernacularTitle:基于脂质组学的整合素αvβ6对结肠癌细胞的促癌机制研究
- Author:
Ben-Jia LIANG
1
;
Yang-Bin FU
;
Jin-Tao YU
;
Jun WANG
;
Jun NIU
;
Ming-Liang ZHOU
Author Information
1. 山东第一医科大学附属省立医院 胃肠外科(山东 济南 250021)
- Keywords:
Colon tumor;
Integrin αvβ6;
Lipidomics;
Lipid metabolism
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(9):678-683
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of integrin αvβ6 on lipid metabolism in colon cancer cells;to identify potential metabolic biomarkers for the diagnosis of colon cancer.Meth-ods:Liquid chromatography-mass spectrometry(LC-MS)-based lipidomic analysis was utilized to investigate the effects of αvβ6 on the changes in SW480 metabolism in colon cancer cell lines.The partial least squares discriminant analysis model showed different lipid profiles in Integrin αvβ6 over-expressed or low-expressed SW480.Results:After Integrin αvβ6 overexpression,a total of 252 lipids showed significant differences in SW480 cells,of which 138 showed up-regulation and 114 showed down-regulation.Moreover,the Methyl phosphatidylcholine(MePC),phosphatidyl-choline(PC),phosphatidylethanolamine(PE)and triglycerides(TG)were also found to have good diagnostic potential in αvβ6 overexpressing cancer cells.Conclusion:Integrin αvβ6 may promote cancer cell invasivness and metastasis by regulating pathways of dysregulated lipid metabolism.These results may provide potential clues to the molecular mechanisms of Integrin αvβ6 on colon cancer cells.
