Expression of MRPL37 in colorectal cancer and correlation with clinicopathology
10.3969/j.issn.1009-9905.2024.07.003
- VernacularTitle:MRPL37在结直肠癌中的表达及与临床病理的相关性
- Author:
Wen-Hao TENG
1
;
Li-Liang HAO
;
Guang LI
;
Xin-Rui CHEN
Author Information
1. 锦州医科大学临沂市人民医院 研究生培养基地(山东 临沂 276007)
- Keywords:
Colorectal cancer;
MRPL37;
Biomarkers;
Lymphocyte;
Tumor immune microenvironment
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(7):517-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate expression and significance of mitochondrial ribosomal protein L37(MRPL37)in colorectal cancer.Methods:RNA-seq data and clinical information of colorectal cancer patients were obtained from the TCGA and GEO databases to analyze the differ-ential expression,clinicopathological features,and prognosis of MRPL37 in colorectal cancer.En-richment analysis was performed to explore the biological functions and signaling pathways in-volved in MRPL37,and the TISID database was analyzed for the correlation between MRPL37 and immune-infiltrating cells.Results:MRPL37 was found to be significantly overexpressed in colorectal cancer(P＜0.05)and was significantly correlated with the T-stage(P=0.0041),N-stage(P=0.0053),and TNM-stage(P=0.0159)of colorectal cancer patients.The enrichment analysis indi-cates that MRPL37 is primarily involved in mitochondrial physiological activities,cell cycle,oxida-tive phosphorylation,and immune pathways in colorectal cancer.Regarding tumor immunity,changes in MRPL37 expression were found to be correlated with changes in multiple types of im-mune cells in the tumor microenvironment.MRPL37 was an independent prognostic factor(P=0.011),and its expression level was positively associated with patient prognosis(P=0.0017).Con-clusion:MRPL37 may serve as a new potential biomarker for colorectal cancer,which can be used in the future to predict patient prognosis and guide precise patient treatment.
