Expression of ZIC5 protein in breast cancer and its relation-ship with clinicopathological characteristics and surgical prognosis
10.3969/j.issn.1009-9905.2024.06.007
- VernacularTitle:乳腺癌组织ZIC5蛋白表达与临床病理特征和手术预后的关系
- Author:
Jian-Ye ZHANG
1
;
Ying MA
;
Zhan-Hua QI
Author Information
1. 青海省交通医院 外一科(青海 西宁 810001)
- Keywords:
Breast neoplasms;
Zinc finger structure of cerebellum 5;
Clinicopathological char-acteristics;
Surgical prognosis
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(6):458-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the expression of cerebellar zinc finger structure 5(ZIC5)protein in breast cancer and its clinicopathological characteristics,surgical prognosis.Methods:A total of 128 breast cancer patients,who were admitted to our hospital be-tween June 2016 and December 2017,were enrolled in this study.Immunohistochemistry was employed to assess the expression of ZIC5 protein.The positive expression rate of ZIC5 protein in breast cancer tissues was compared with that in normal surgical margin tissues.Additionally,an analysis was conducted to explore the association between the expression of ZIC5 protein and various clinical pathological characteristics of breast cancer patients,as well as its correlation with prognosis.Results:The positive expression rate of ZIC5 protein in breast cancer tissue was higher than that in normal tissue of resection margin.The postoperative survival rate of breast can-cer patients was 81.37％.TNM stage Ⅲ～Ⅳ,undifferentiated/poorly differentiated,tumor diam-eter ≥ 2 cm,invasion depth T3～T4,lymph node metastasis,ZIC5 protein positive expression were all risk factors for poor prognosis of breast cancer surgery.(RR=4.405,5.153,4.520,2.211,3.137,6.079,P＜0.05).The survival rate of patients with negative ZIC5 protein expression in breast cancer tissue was higher than that of patients with positive ZIC5 protein expression(P＜0.05).Conclu-sion:The positive expression rate of ZIC5 protein in breast cancer tissue is higher than that in nor-mal tissue of resection margin,and the expression of ZIC5 protein in cancer tissue is related to clinical stage,tumor differentiation,tumor size,invasion depth,and lymph node metastasis.The above indicators are risk factors for poor prognosis of breast cancer surgery.
