Clinical value of thrombospondin-1 and transforming growth actor-β in predicting post hepatectomy liver failure
10.3969/j.issn.1009-9905.2024.06.004
- VernacularTitle:TSP-1和TGF-β在预测肝部分切除术后肝衰竭的临床价值
- Author:
Hasimu HAXIAOBIEKE
1
;
Jing WU
;
Gang YAO
;
Apaer SHADIKE
;
Fulati XIAPUKAITI
;
Yun-Fei ZHANG
;
Tuersunmaimaiti ABUDUSHALAMUU
;
Tuxun TUERHONGJIANG
Author Information
1. 新疆医科大学第一附属医院肝脏·腹腔镜外科(新疆 乌鲁木齐 830054)
- Keywords:
Post hepatectomy liver failure;
Thrombospondin 1;
Transforming growth factor β
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(6):442-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the dynamic changes of thrombosbondin-1(TSP-1)and transforming growth factor beta(TGF-β)in patients who underwent hepatectomy and their clinical value in predicting post-hepatectomy liver failure(PHLF).Methods:Clinical data of 113 patients who received hepatectomy in the First Affiliated Hospital of Xinjiang Medical University from Janu-ary 2016 to March 2019 were retrospectively analyzed.The cohort comprised 59 males and 54 fe-males,with an average age of(41.00±13.98)years.According to the standard of the International Study Group of Liver Surgery(ISGLS),TSP-1 was divided into the PHLF group(n=40)and the non-PHLF group(n=73).The dynamic changes of plasma TSP-1 and TGF-β plasma levels during peri-operative period were observed.The definition and diagnostic criteria suggested by ISGLS was used to evaluate PHLF.The value of plasma TSP-1 and TGF-β level in predicting PHLF were ana-lyzed by calculating areas under the receiver operating characteristic curves(AUCs).Patients were divided into TSP-1 high group and TSP-1 low groups based upon the ROC cutoff values and their correlation with PHLF was analyzed.T test and Mann-Whitney rank sum test were performed to compare the TSP-1 and TGF-β levels between the two groups.The rate comparison was carried out by Chi-square test or Fisher's exact test.Results:In this study,40 patients experienced vary-ing degrees of PHLF.The plasma levels of TSP-1 on postoperative day I(POD1)and day 7(POD 7)in the PHLF group were significantly higher than those in the non-PHLF group(P＜0.05,P＜0.01,re-spectively).The area under the ROC curve of plasma TSP-1 level on postoperative 1 d in the diag-nosis of PHLF was 0.725,with sensitivity of 0.864 and specificity of 0.647.The area under the ROC curve of plasma TSP-1 level on postoperative 7 d in the diagnosis of PHLF was 0.81,with sensitiv-ity of 0.818 and specificity of 0.765.Conclusion:The incidence of PHLF is related to the extent of liver resection,Child-Pugh grade and TSP-1 levels on postoperative day 1.The concentration level of TSP-1 on POD land 7 might be utilized as an effective marker for predicting PHLF.
