Research progress on the role of immune cells regulated by Maresin-1 in inflammatory diseases
10.3760/cma.j.cn121430-20240104-00016
- VernacularTitle:Maresin-1调节免疫细胞在炎症性疾病中的作用研究进展
- Author:
Ping LIU
1
;
Guangyan ZHU
;
Haifa XIA
Author Information
1. 华中科技大学同济医学院附属协和医院麻醉科，麻醉与危重病研究所，麻醉复苏教育部国家重点实验室，湖北武汉 430022
- Keywords:
Maresin-1;
Immune cell;
Inflammatory disease
- From:
Chinese Critical Care Medicine
2024;36(10):1113-1116
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation reaction is a host defense mechanism that protects the host from harmful external antigens and microorganisms, and the intensification of inflammation reaction can lead to tissue damage and development of systemic inflammatory diseases. As a representative derivative of ω-3 fatty acids, Maresin-1 has been widely explored for its role in regulating innate immune cells (neutrophils and mononuclear/macrophages) and promoting the resolution of infectious inflammation in acute inflammatory diseases. There is now increasing evidence that Maresin-1 also has a direct effect on the adaptive immune system and prevents the transition from acute inflammation to chronic inflammation. By analyzing the literature related to the effect of Maresin-1 on the regulation of inflammation, this paper summarized the role of various immune cells in inflammatory response and the regulatory mechanism of Maresin-1 on various immune cells, so as to deeply understand the research progress of the role of Maresin-1 in regulating immune cells in inflammatory diseases. This study provides a theoretical basis for the basic research and clinical application of Maresin-1 in inflammatory diseases.
