Research progress on the correlation between intestinal microecology and sepsis
10.3760/cma.j.cn121430-20231117-00988
- VernacularTitle:肠道微生态与脓毒症的研究进展
- Author:
Zhiyi LIU
1
;
Guanghui XIU
Author Information
1. 云南大学附属医院（云南省第二人民医院）重症医学科，昆明 650021
- Keywords:
Gut microbiome;
Sepsis;
Infection;
Host-microbiota interaction;
Dysbiosis
- From:
Chinese Critical Care Medicine
2024;36(8):882-886
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, with increasing mortality as septic shock and organ failure progress. Mechanisms such as vascular endothelial dysfunction, microcirculatory disorders, coagulation abnormalities, immune suppression, mitochondrial damage, cell pyroptosis, ferroptosis, endoplasmic reticulum stress, and autophagy play crucial roles in organ dysfunction and death caused by sepsis. Concurrently, the imbalance of the gut microbiota also plays an undeniable role in the development of sepsis, with recent studies demonstrating a close connection between the gut microbiome and sepsis. Thus, how to improve the prognosis of patients with sepsis by reconstructing gut microbiota has become a focus of interest for critical care physicians. This article reviews the research progress on the correlation between gut microbiota and sepsis, providing clinical physicians with more therapeutic strategies to improve patient prognosis.
