Current research status and prospects of ginseng's regulatory effect on immune dysfunction caused by "acute deficiency syndrome" of sepsis
10.3760/cma.j.cn121430-20240422-00366
- VernacularTitle:中药人参对脓毒症"急性虚证"免疫抑制调节作用的研究现状与展望
- Author:
Kaiqiang ZHONG
1
;
Rui CHEN
;
Jun LI
;
Xiaotu XI
Author Information
1. 广东省中医院（广州中医药大学第二附属医院，广州中医药大学第二临床医学院）急诊科，广州 510120
- Keywords:
Sepsis;
Ginseng;
Acute deficiency syndrome;
Immune dysfunction
- From:
Chinese Critical Care Medicine
2024;36(7):681-686
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a prevalent critical illness observed in emergency intensive care unit (ICU), characterized by life-threatening organ dysfunction caused by infection-induced inflammatory immune disorders in the body. The suppression of immune function plays a crucial role in the development and progression of sepsis. Traditional Chinese medicine theory of "acute deficiency syndrome" in sepsis shares similarities with the concept of "immunosuppression". According to this theory, ginseng is frequently utilized in clinical treatment of sepsis due to its ability to invigorate vitality and strengthen the body, playing a crucial role in tonifying deficiency and improving the overall health of patients. This paper provides a detailed discussion of the pathophysiological mechanisms of sepsis immune dysfunction and its correlation with "acute deficiency syndrome" in traditional Chinese medicine. It summarizes the current state of modern pharmacological research on ginseng's impact on the body's immune function, discusses relevant research progress and shortcomings regarding ginseng's therapeutic effects on immunosuppression in sepsis, and proposes future research directions.
