Protective effect and mechanism of resveratrol on vascular endothelial cells
10.3760/cma.j.cn121430-20240103-00011
- VernacularTitle:白藜芦醇保护血管内皮细胞的作用与机制
- Author:
Yang YANG
1
;
Hong ZHANG
;
Zhenkui LIU
;
Zigang ZHAO
Author Information
1. 河北北方学院微循环研究所，河北张家口 075000
- Keywords:
Resveratrol;
Vascular endothelial cell;
Nitric oxide;
Oxidative stress;
Apoptosis
- From:
Chinese Critical Care Medicine
2024;36(6):664-668
- CountryChina
- Language:Chinese
-
Abstract:
Resveratrol is a polyphenolic plant extract with many biological activities such as anti-inflammation and anti-oxidative stress. Vascular endothelial cell (VEC) is the main sites for maintaining normal vascular permeability and participating in vasomotor regulation and substance exchange. VEC injury plays a key role in various diseases or pathological processes such as cardiovascular disease, chronic inflammation and sepsis. Studies have shown that resveratrol protects VEC and reduces endothelial damage by regulating nitric oxide (NO) and its related enzymes, reducing oxidative stress and inhibiting apoptosis, thereby exerting beneficial effects.
