Research progress in the mechanism of intestinal environmental disturbance on the occurrence and development of sepsis-associated liver injury

VernacularTitle:肠道环境紊乱对脓毒症相关肝损伤发生发展的机制研究进展
Author: Tianwei WANG ¹ ; Hailong YU ; Jiangquan YU ; Jun SHAO ; Ruiqiang ZHENG
Author Information

1. 扬州大学附属苏北人民医院，江苏省苏北人民医院重症医学科，江苏扬州　225001
Keywords: Sepsis; Liver injury; Gut microbiota; Intestinal barrier
From: Chinese Critical Care Medicine 2024;36(6):660-663
CountryChina
Language:Chinese
Abstract: Sepsis-associated liver injury (SALI) is a common complication of sepsis, which is characterized by systemic immune disorders induced by sepsis leading to liver damage. Currently, there are no effective treatments for SALI, which is related to its complex pathophysiological mechanisms. In recent years, the disorder of intestinal environment after sepsis has been considered as an important factor for SALI, but the specific molecular mechanism of the above process is still unclear. This article will review the pathological role and molecular mechanisms between intestinal environmental disturbance and SALI, aiming to analyze the potential research direction of SALI and identify potential therapeutic targets for its treatment.