Role and mechanism of intestinal-liver interaction in infectious intestinal/liver injury

VernacularTitle:肠-肝互作在感染性肠/肝损伤中的作用及机制
Author: Hongyan XIAO ¹ ; Huaping LIANG ; Junyu ZHU
Author Information

1. 陆军军医大学大坪医院战伤感染与特需药品研究室，创伤与化学中毒全国重点实验室，重庆　400042
Keywords: Infection; Intestinal-liver interaction; Intestinal barrier; Bile acid
From: Chinese Critical Care Medicine 2024;36(6):656-659
CountryChina
Language:Chinese
Abstract: Infection is a common medical problem at present. Different pathogens can lead to different infections. Severe infections can ultimately lead to sepsis, resulting in multiple organ dysfunction and the high mortality of patients. Therefore, studying the occurrence and development of severe infections is essential to improve the survival rate of patients. More and more studies have revealed the important role of connection between intestine and liver in infectious diseases. The maintenance of intestinal mechanical barrier and biological barrier function and the regulation of intestinal flora metabolites can reduce infectious liver injury. Bile acids are important metabolites in the liver, which can inhibit the progression of certain infectious intestinal injuries and promote intestinal damage caused by certain pathogens. In this article, the mechanism of action of the intestinal-liver axis in infection was reviewed to find a new target for the treatment of clinical infection.