Research progress on the role of endothelial mechanically sensitive ion channel protein Piezo1 in diseases
10.3760/cma.j.cn121430-20230911-00775
- VernacularTitle:内皮细胞机械敏感离子通道蛋白Piezo1在疾病中作用的研究进展
- Author:
Xiaoting ZHANG
1
;
Jinhai LIU
;
Xiaoming DENG
;
Lulong BO
Author Information
1. 海军军医大学第一附属医院麻醉学部，上海 200433
- Keywords:
Endothelial cell;
Piezo1;
Cardiovascular system;
Respiratory system
- From:
Chinese Critical Care Medicine
2024;36(5):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial cells have important physiological functions and regulatory effects related to the occurrence and development of various diseases. Piezo1 is a mechanically sensitive ion channel protein, which is widely distributed in various tissues of the body and participates in the occurrence and development of various diseases. Piezo1 is highly expressed in endothelial cells and plays an important regulatory role in endothelial cell function. This article reviews the structure and function of Piezo1, the physiological function and pathological damage mechanism of endothelial cells, and the role of endothelial cell Piezo1 in various diseases, in order to understand the function and regulation mechanism of endothelial cell Piezo1, and provide new targets and strategies for the treatment of related diseases.
