Research progress on the dynamic role and intervention value of autophagy in neonatal hypoxic-ischemic brain damage
10.3760/cma.j.cn121430-20231022-00891
- VernacularTitle:新生儿缺氧缺血性脑损伤中自噬的动态作用及干预价值的研究进展
- Author:
Yue HE
1
;
Yuyuan LIU
;
Zhifeng WU
Author Information
1. 陆军军医大学第二附属医院儿科，重庆 400037
- Keywords:
Autophagy;
Hypoxic-ischemic brain damage;
Hypoxic ischemia;
Autophagy-related gene;
Cerebral palsy;
Newborn;
Neuroprotection
- From:
Chinese Critical Care Medicine
2024;36(5):552-556
- CountryChina
- Language:Chinese
-
Abstract:
The repair of the nervous system after hypoxic-ischemic brain damage (HIBD) in neonates lacks specific therapeutic approaches, posing a challenge and hot topic in the medical field. Autophagy, as a cellular self-repair mechanism, plays a role through different signaling pathways at different stages, yet its specific roles and mechanisms in different stages of HIBD remain unclear. This article reviews the recent research advancements on autophagy in different neonatal HIBD stages: heightened autophagic activity manifests during the acute hypoxic-ischemic phase, with its neuroprotective or deleterious impact subject to ongoing debate; during the subacute and chronic phases, autophagy exert dual effects on neuronal death and repair; in sequelae period, autophagy-related studies are still insufficient, but the expression levels of autophagy-related genes (ATG) in children with cerebral palsy suggest both positive and negative aspects of autophagy post-HIBD. Collectively, optimal autophagic flux facilitates the elimination of detrimental substrates and toxic proteins, thereby engendering neuroprotection. Further studies on the roles and mechanisms of autophagy in HIBD therapy holds promise for devising efficacious preventative and therapeutic strategies rooted in autophagy, and to improve the survival rate and quality of life of the children.
