Research progress on the role of astrocytes in cerebral ischemia/reperfusion injury

VernacularTitle:星形胶质细胞在脑缺血/再灌注损伤中作用的研究进展
Author: Anyang ZHANG ¹ ; Zhaoshuo LI ; Zhigang LU
Author Information

1. 荆门市中心医院神经内科，湖北荆门　448000
Keywords: Astrocyte; Cerebral ischemia/reperfusion injury; Oxidative stress
From: Chinese Critical Care Medicine 2024;36(4):441-444
CountryChina
Language:Chinese
Abstract: The pathophysiological mechanism of cerebral ischemia/reperfusion injury (CIRI) is complex, and the current treatment methods are limited and the efficacy is not good. Previous therapeutic strategies of CIRI mostly target neurons, but no significant progress has been made. At present, astrocytes are expected to be promising effector cells for the treatment of CIRI. Astrocytes are a "double-edged sword" in the pathological process of CIRI, with both neurotoxic and neuroprotective effects on the central nervous system. How to effectively use astrocytes to treat CIRI has become a research hotspot. In this review, the dual roles of astrocytes in CIRI mechanism were reviewed, and the related mechanisms of astrocytes in relieving oxidative stress induced by CIRI were emphasized, in order to provide new ideas for the treatment of CIRI.