cGAS-cGAMP Signaling and Antiviral Defense.
10.4167/jbv.2014.44.1.112
- Author:
Zahid MANZOOR
1
;
Young Sang KOH
Author Information
1. Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea. yskoh7@jejunu.ac.kr
- Publication Type:Letter
- Keywords:
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS);
Type I interferons;
DNA sensor;
Antiviral defense
- MeSH:
Animals;
Cytosol;
Dendritic Cells;
DNA;
DNA Virus Infections;
Fibroblasts;
Guanosine;
Herpesvirus 1, Human;
Immunity, Innate;
Interferon Type I;
Macrophages;
Mice;
Transfection
- From:Journal of Bacteriology and Virology
2014;44(1):112-114
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that plays an important role in innate immunity. Transfection of DNA or DNA virus infection results in the induction of type I interferon production in fibroblasts, macrophages, and dendritic cells which is dependent on cGAS. Recently, cGas (-/-) mice have been reported to be more vulnerable to fatal infection with herpes simplex virus 1 (HSV1) as compared to wild-type mice.
