A Causal Analysis of Hypothyroidism and Nonalcoholic Fatty Liver Disease based on Mendelian Randomization

VernacularTitle:基于孟德尔随机化的甲状腺功能减退症与非酒精性脂肪性肝病的因果分析
Author: Dongdong WANG ^{1
,

2} ; Mengyao GAO ; Huaxia MU
Author Information

1. 山东第二医科大学公共卫生学院(261053)
2. 中国医科大学公共卫生学院
Keywords: Hypothyroidism; Nonalcoholic fatty liver disease; Mendelian randomization; Causality
From: Chinese Journal of Health Statistics 2024;41(3):398-403
CountryChina
Language:Chinese
Abstract: Objectives To explore the causal relationship between hypothyroidism and nonalcoholic fatty liver disease(NAFLD)by two-sample Mendelian randomization.Methods Genome-wide association study(GWAS)data was used to identify genetic variation data associated with hypothyroidism as instrumental variables(IVs).MR-Egger regression,inverse variance weighting method(IVW)and weighted median method(WME)were used to examine the causal effects between hypothyroidism and NAFLD.The causal association was evaluated with OR.Results A total of 334 SNP loci were included as Ⅳ,and there was no heterogeneity and pleiotropy in the Ivs.Based on IVW estimation mryhod,the OR with 95%CI of two different sets were 21.30(95%CI:93.61～125.50)]and 5.79(95%CI:1.03～32.47),which both indicated a significant causal association between the hypothyroidism and NAFLD(P＜0.05).What′s more,the results of Mendelian randomization were robust.Conclusion Hypothyroidism is potentially associated with NAFLD.