Multioxidized polyketides from an endophytic Penicillium sp.YUD17006 associated with Gastrodia elata
10.1016/S1875-5364(24)60724-7
- Author:
Hongtao LI
1
;
Ruining YANG
;
Fei XIE
;
Tianpeng XIE
;
Linhuan TANG
;
Hao ZHOU
;
Zhongtao DING
Author Information
1. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical Uni-versity,Kunming 650500,China
- Keywords:
Penicillium sp.;
Multioxidized polyketides;
Secondary metabolite;
Anti-acetylcholinesterase activity;
PTP1B inhibit-ory activity
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(11):1057-1064
- CountryChina
- Language:Chinese
-
Abstract:
Three novel,highly oxygenated polyketides,multioketides A-C(1-3),and three previously described multioxidized aromatic polyketides(4-6),were isolated from an endophytic Penicillium sp.YUD17006 associated with Gastrodia elata.Their chem-ical structures were elucidated using extensive spectroscopic data,electronic circular dichroism calculations,and single X-ray diffrac-tion analysis.All metabolites were characterized by a typical α,β-unsaturated ketone fragment and exhibited a high degree of oxidation.Multioketides A and B were identified as a pair of epimers featuring a rare dihydroisobenzofuranone core.Multioketide C possessed a novel 5/6/6/6 heterotetracyclic chemical architecture with unusual 1,4-dioxin functionalities.Plausible biosynthetic pathways for 1-6 were proposed.Additionally,compound 3 demonstrated weak inhibitory activities against both acetylcholinesterase and protein tyr-osine phosphatase 1B.
