Talaketides A-G,linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp.SCSIO 41027
10.1016/S1875-5364(24)60659-X
- Author:
Chunmei CHEN
1
;
Xueni WANG
;
Wenxuan FANG
;
Jiaqi LIANG
;
Jian CAI
;
Dehua YANG
;
Xiaowei LUO
;
Chenghai GAO
;
Xiangxi YI
;
Yonghong LIU
;
Xuefeng ZHOU
Author Information
1. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China
- Keywords:
Mangrove sediment-derived fungus;
Talaromyces sp.;
Linear polyketides;
Cytotoxicity;
Prostate cancer
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(11):1047-1056
- CountryChina
- Language:Chinese
-
Abstract:
Seven novel linear polyketides,talaketides A-G(1-7),were isolated from the rice media cultures of the mangrove sed-iment-derived fungus Talaromyces sp.SCSIO 41027.Among these,talaketides A-E(1-5)represented unprecedented unsaturated lin-ear polyketides with an epoxy ring structure.The structures,including absolute configurations of these compounds,were elucidated through detailed analyses of nuclear magnetic resonance(NMR)and high-resolution mass spectrometry(HR-MS)data,as well as elec-tronic custom distributors(ECD)calculations.In the cytotoxicity screening against prostate cancer cell lines,talaketide E(5)demon-strated a dose-dependent inhibitory effect on prostate cancer PC-3 cell lines,with an IC50 value of 14.44 μmol·L-1.Moreover,com-pound 5 significantly inhibited the cloning formation of PC-3 cell lines and arrested the cell cycle in S-phase,ultimately inducing ap-optosis.These findings indicate that compound 5 may serve as a promising lead compound for the development of a potential treat-ment for prostate cancer.
