NO inhibitory constituents from Glycosmis craibii var.glabra
10.1016/S1875-5364(24)60632-1
- Author:
Hongwei CHEN
1
;
Meng DING
;
Jun LIN
;
Shuo YUAN
;
Kewu ZENG
;
Pengfei TU
;
Yong JIANG
Author Information
1. State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China
- Keywords:
Glycosmis craibii var.glabra;
Quinolone;
Flavanone;
NO inhibition
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(11):1040-1046
- CountryChina
- Language:Chinese
-
Abstract:
Six novel compounds,comprising three quinolones(1a,1b,and 2)and three flavanones(3-5),along with seven known analogs(6-13),were isolated from the 95％EtOH extract of the stems and leaves of Glycosmis craibii var.glabra.The structures of the new compounds were elucidated using HR-ESI-MS,UV,and 1D and 2D nuclear magnetic resonance(NMR)data analysis.The ab-solute configurations were determined through Mosher ester and electronic circular dichroism(ECD)spectral analysis.Compounds 2,6,9,and 10 demonstrated inhibition of nitric oxide(NO)production stimulated by lipopolysaccharide in BV-2 microglial cells,with IC50 values ranging from 13.5 to 20.1 μmol·L-1,comparable to the positive control,dexamethasone.
